The fibrous proteins and ground substance produced by fibroblasts are what constitute the extracellular matrix (ECM), which makes up the bulk of connective tissue. The ECM has many roles within ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...

Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases have not improved. This will be changed by increasing knowledge of new pathogenetic mechanisms, which ...

J Gastroenterol Hepatol. 2008;23(7):1024-1035. Cite this: Changing the Pathogenetic Roadmap of Liver Fibrosis? Where Did It Start; Where Will It Go? - Medscape - Jul 01, 2008. 1869 F. Boll Star-shaped ...

University researchers have developed a new connective tissue model to study disorders like fibrosis, a type of scarring that occurs when damage to the body causes normal tissue to be replaced by hard ...

Collagen is a major protein which is found in connective tissues and the extracellular matrix (ECM). Helical in structure, at least 27 types of collagen have been identified in the human body, with ...

The increased deposition of connective tissue is a problem in chronic diseases of many organs such as the lungs (idiopathic pulmonary fibrosis), liver (cirrhosis), kidneys (kidney fibrosis), gut ...

Extracellular vesicles (EVs) have rapidly emerged as one of the most promising frontiers in modern biology. These nano-sized ...